Mutt and JeffMutt and Jeff.

Mutt and Jeff is a long-running American newspaper comic strip created by cartoonist Bud Fisher in 1907 about "two mismatched tinhorns". It is commonly regarded as the first daily comic strip. The concept of a newspaper strip featuring recurring characters in multiple panels on a six-day-a-week schedule had previously been pioneered through the short-lived A. Piker Clerk by Clare Briggs, but it was Mutt and Jeff as the first successful daily comic strip that staked out the direction of the future trend.